Address correspondence to Alfredo Berardelli, Department of Neurology and Psychiatry and Neuromed Institute, "Sapienza" University of Rome, Viale dell'UniversitA , 30, 00185 Rome, Italy. Email: To investigate whether visuomotor integration processes induce long-term potentiation and depression -like plasticity in the primary motor cortex , we designed a new paired associative stimulation protocol coupling left primary visual area activation achieved by hemifield visual evoked potentials and transcranial magnetic stimulation over the left M1, at specific interstimulus intervals , delivered at 1 Hz .
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